基本信息

工作经历

2018至今  中国农业大学昆虫学系 副教授

2016-2017 哈佛医学院Norbert Perrimon教授实验室 访问学者

2012-2017 中国农业大学昆虫学系 讲师

2009-2012 中国科学院生物物理研究所 博士后

教育经历

2002-2009 中国科学院遗传与发育生物学研究所 博士

1998-2002 武汉大学 微生物学专业 学士

教学工作

本科生课程：分子生物学导论，普通昆虫学实验

研究生课程：昆虫发育生物学

研究方向

主要研究方向：昆虫发育生物学

1. 模式昆虫果蝇器官发育和衰老的机理：重要的信号分子对翅细胞形貌发生、增殖、存活、运动等过程的作用机理，脂肪体表达蛋白对器官发育和衰老的作用。

2. 农业昆虫的功能基因组学：鉴定农业昆虫的关键基因，利用RNAi和转基因技术破坏害虫的关键基因，揭示农业昆虫器官发育、活动规律及其调控途径，为利用遗传学手段控制害虫种群数量提供理论支持，开发RNA农药。

科研项目

国家重点研发计划子课题2项（2022-2025，2022-2026）；

国家自然科学基金面上项目（2019-2022）；

北京市自然基金面上项目（2019-2021）；

高等学校博士学科点专项科研基金（2014-2016）；

国家自然科学基金青年基金项目（2011-2013）。

代表性论著

代表性论文（# equal contribution ; * corresponding author）：

Sun, X., Shen, J., Perrimon, N., Kong, X., Wang, D.*, 2023. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Nature Communications. 14:6254. doi: 10.1038/s41467-023-42042-7.

Zhou, P., Zong, X., Yan, S., Zhang, J., Wang, D.*, Shen J.*, 2023. The Wnt pathway regulates wing morph determination in Acyrthosiphon pisum. Insect Biochemistry and Molecular Biology 161, 104003. doi: 10.1016/j.ibmb.2023.104003.

Chen, M., Gao, E., Lin, G., Shen, J., Wang, D.*, 2023. The transcription factor optomotor-blind restricts apterous expression through TrxG and PcG genes. Developmental Biology 497, 59-67. doi: 10.1016/j.ydbio.2023.03.002.

Qu, X.#, Wang, S.#, Lin, G., Li, M., Shen, J., Wang, D.*, 2022. The synergistic effect of thiamethoxam and synapsin dsRNA targets neurotransmission to induce mortality in Aphis gossypii. International Journal of Molecular Sciences 23, 9388. doi: 0.3390/ijms23094543.

Lu, J., Wang, Y., Wang, X., Wang, D.*, Pflugfelder, G.O., Shen, J.*, 2022. The Tbx6 transcription factor Dorsocross mediates Dpp signaling to regulate Drosophila thorax closure. International Journal of Molecular Sciences 23, 4543. doi: 10.3390/ijms23094543.

Zhou, H., Wang, W., Yan, S., Zhang, J., Wang, D.*, Shen, J.*, 2022. JAK/STAT signaling regulates the Harmonia axyridis leg regeneration by coordinating cell proliferation. Developmental Biology 483, 98-106. doi: 10.1016/j.ydbio.2022.01.002.

Droujinine, I.A., Meyer, A.S.#, Wang, D.#, Udeshi, N.D.#, Hu, Y., Rocco, D., McMahon, J.A., Yang, R., Guo, J., Mu, L., Carey, D.K., Svinkina, T., Zeng, R., Branon, T., Tabatabai, A., Bosch, J.A., Asara, J.M., Ting, A.Y., Carr, S.A., McMahon, A.P., Perrimon, N.*, 2021. Proteomics of protein trafficking by in vivo tissue-specific labeling. Nature Communications 12:2382.  doi: 10.1038/s41467-021-22599-x.

Zhou, H., Ma, Z., Wang, Z., Yan, S., Wang, D.*, Shen, J.*, 2021. Hedgehog signaling regulates regenerative patterning and growth in Harmonia axyridis leg. Cellular and Molecular Life Sciences, 78:2185-2197. doi: 10.1007/s00018-020-03631-7.

Xu, Y., Wei, W., Lin, G., Yan, S., Zhang, J., Shen, J.*, Wang, D.*, 2021. The Ras/MAPK pathway is required for regenerative growth of wing discs in the black cutworm Agrotis ypsilon. Insect Biochemistry and Molecular Biology 131, 103552. doi: 10.1016/j.ibmb.2021.103552.

Fan, Z., Zhang, J., Wang, D.*, Shen, J.*, 2021. T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner. Insect Biochemistry and Molecular Biology 129, 103516. doi: 10.1016/j.ibmb.2020.103516.

Fan, W.M., Luo, D., Zhang, J.Z., Wang, D.*, Shen, J.*, 2021. Vestigial suppresses apoptosis and cell migration in a manner dependent on the level of JNK-Caspase signaling in the Drosophila wing disc. Insect Science 28, 63-76. doi: 10.1111/1744-7917.12762.

Ai, X., Wang, D.*, Zhang, J., Shen, J.*, 2020. Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc. Development 147(22):dev190124. doi: 10.1242/dev.190124.

Sun, J., Zhang, J., Wang, D.*, Shen, J.*, 2020. The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila. Biology Open 9. doi: 10.1111/1744-7917.12762.

Wang, D., Li, J., Liu, S., Zhou, H., Zhang, L., Shi, W., Shen, J.*, 2017. spalt is functionally conserved in Locusta and Drosophila to promote wing growth. Scientific Reports 7, 44393. doi: 10.1038/srep44393.

Wang, D., Li, L., Lu, J., Liu, S., Shen, J.*, 2016. Complementary expression of optomotor-blind and the Iroquois complex promotes fold formation to separate wing notum and hinge territories. Developmental Biology 416: 225-234. doi: 10.1016/j.ydbio.2016.05.020.

Zhao, L.#, Wang, D.#, Wang, Q., Rodal, A.A., Zhang, Y.Q.*, 2013. Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. PLoS Genetics 9, e1003450. doi: 10.1371/journal.pgen.1003450.

Wang, D., Zhang, L., Zhao, G., Wahlstrom, G., Heino, T.I., Chen, J., Zhang, Y.Q.*, 2010. Drosophila twinfilin is required for cell migration and synaptic endocytosis. Journal of Cell Science 123, 1546-1556. doi: 10.1242/jcs.060251.

奖励情况

2018 本科生百篇优秀毕业论文优秀指导教师奖；

2017 北京昆虫学会青年优秀科技论文优秀奖；

2017 第二届中国科协优秀科技论文二等奖；

2016 植物保护学报2016年度优秀论文。