报告题目： Antiviral RNAi in plants and animals

报告人： Prof. Shouwei Ding

报告人单位： University of California at Riverside

报告时间： 2017年11月2日 10：00-11:30

报告地点：生命科学中心2018室

联系人：范在丰（32771），周涛（32115）

DING SHOU-WEI教授1996～1999年: 任新加坡国立大学分子农业生物学院研究室主任；

2000年12月至今任加州大学河滨校区植物病理学系教授。他发现了黄瓜花叶病毒编码的RNA沉默抑制子2b，在植物和动物中存在的RNAi介导的免疫反应研究方面做出了杰出贡献，在Science, Nature, Cell等国际学术期刊发表了70余篇高水平论文。

1. Guo, Z., Lu, J., Wang, X., Zhan, B., Li, W., Ding, S. 2017. Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis. Proc Natl Acad Sci USA. 114: 1377-1382.

2. Li, Y., Basavappa, M., Lu, J., Dong, S., Cronkite, D., Prior, J., Reinecker, H., Hertzog, P., Han, Y.H., Li, W.X., Cheloufi, S., Karginov, F., Ding, S.W., Jeffrey, K. 2016. Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Nature Microbiology. 2:16250.

3. Cao, M.J., Du, P., Wang, X., Yu, Y., Qiu, Y., Li, W., Gal-On, A., Zhou, C., Li, Y., Ding, S. 2014. Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. Proc Natl Acad Sci USA. 111:14613–14618.

4. Li, Y., Lu, J., Han, Y.H., Fan, X., Ding, S. 2013. RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals. Science 342:231-234.

5. Wu Q, Wang Y, Cao MJ, Pantaleo V, Burgyan J, Li WX and Ding SW (2012) Homology-Independent Discovery of Replicating Pathogenic Circular RNAs by Deep Sequencing and a New Computational Algorithm. Proc Natl Acad Sci USA 109:3938-3943.

6. Duan CG, Fang YY, Zhou BJ, Zhao JH, Hou WN, Zhu H, Ding SW, Guo HS. 2012. Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the cucumber mosaic virus 2b protein. Plant Cell 24:259-274.

7. Wang XB, Jovel J, Udomporn P, Wang Y, Wu Q, Li WX, Gasciolli V, Vaucheret H and Ding SW. 2011. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative Argonautes in Arabidopsis thaliana. Plant Cell  23:1625-38

8. Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, and Ding SW. 2010. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci U S A. 107, 1606-1611.

9. Wang XB, Wu Q, Ito T, Cillo F, Li WX, Chen X, Yu JL, and Ding SW. 2010. RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. Proc Natl Acad Sci U S A 107, 484-489.

10. Ding SW. RNA-based viral immunity. 2010. Nature Rev Immunol 10:632-44 (on the cover).

11. Wu Q, Wang XB and Ding SW. 2010. Viral suppressors of RNA-based viral immunity: Host targets. Cell Host & Microbe 8:12-15. (invited review). 

12. Aliyari R, and Ding SW. 2009. RNA-based viral immunity initiated by the Dicer family of host immune receptors. Immunol Rev 227: 176-188. (invited review).

13. Elkashef S and Ding SW. 2009. Possible new RNA intermediate in RNA silencing. Nature Chem Biol 5:278-9. (commentary)

14. Aliyari R, Wu QF, L HW, Wang XH, Li F, Green LD Han CS, Li WX, and Ding SW. 2008. Mechanism of induction and suppression of antiviral immunity directed by small RNAs in Drosophila. Cell Host & Microbe 4:387-397.

15. Diaz-Pendon JA and Ding SW. 2008. Direct and indirect roles of viral suppressors of RNA silencing in pathogenesis. Ann Rev Phytopath 46:303-326 (invited review).

16. Ding SW and Voinnet O. 2007. Antiviral immunity directed by small RNAs. Cell 130:413-426.

     

     

     

欢迎各位老师和同学参加 ！

中国农业大学植物保护学院

111引智计划

    2017年11月1日