报告题目：Novel approaches to control foodborne and poultry pathogens

报告人：Gireesh Rajashekara教授，美国俄亥俄州立大学

时间：2017年6月8日上午11:00-12:00

地点：人发学院008会议室

联系人：罗来鑫，电话：62731226

报告人简介

Dr. Rajashekara received Ph. D. degree in Microbiology from University of Minnesota in 1999. After four years working as Associate Scientist in Department of Animal Health and Biomedical Sciences, University of Wisconsin, Dr. Rajashekara joined the Ohio State University as Assistant Professor in Food Animal Health Research Program in 2006 and was promoted to professor in 2016.

Dr. Gireesh has served as editor for scientific journals including Poultry science, Animal Health Research Reviews; PLos One, et al. His team also won Distinguished Multidisciplinary Team Research Award for excellence in Team Research, OARDC Vegetable Safety, The Ohio State University.

Dr. Rajashekara’s research is focused on understanding molecular mechanisms of pathogenesis of foodborne zoonotic pathogen, Campylobacter. Particularly, looking at the virulence mechanisms of Cy jejuni. investigating the contribution of poly phosphate (poly P) and Twin Arginine Translocation (TAT) system in C. jejuni stress responses and virulence mechanisms and identify C. jejuni components that are affected by these systems, understand their role in C. jejuni induced disease pathogenesis, and use these information to develop novel antimicrobial strategies against Campylobacter in humans as well as in animal reservoirs.  Also, his laboratory is interested in understanding how gutmicroflora modulates intestinal homeostasis and its impact on pathogenesis of enteric pathogens. Particularly, they are looking at how different lactic acid bacteria modulate host cellular pathways using system biology approach in a gnotobiotic pig model. Further we are interested in studying the interaction of different probiotic bacteria with enteric pathogens including rotavirus.

报告人代表性论文（2015-2017）

1. Kandasamy S, Vlasova AN, Fischer DD, Chattha KS, Shao L, Kumar A, Langel SN, Rauf A, Huang HC, Rajashekara G, Saif LJ. Unraveling the Differences between Gram-Positive and Gram-Negative Probiotics in Modulating Protective Immunity to Enteric Infections. Front Immunol. 2017 Mar 27;8:334. Review.

2. Chandrashekhar K, Kassem II, Rajashekara G. Campylobacter jejuni transducer like proteins: Chemotaxis and Beyond. Gut Microbes. 2017 Jan 12:1-12.

3. Vlasova AN, Paim FC, Kandasamy S, Fischer D, Langel SN, Kumar A, Alhamo MA, Chepngeno J, Shao L, Huang H, Rajashekara G, and Saif, LJ. 2017. Protein malnutrition modifies innate immunity, gene expression by intestinal epithelial cells and human rotavirus infection in neonatal gnotobiotic pigs. mSphere. Mar 1;2(2).

4. Kandasamy S, Vlasova AN, Fischer D, Kumar A, Chattha KS, Rauf A, Shao L, Langel SN, Rajashekara G, Saif LJ. (2016). Differential Effects of Escherichia coli Nissle and Lactobacillus rhamnosus Strain GG on Human Rotavirus Binding, Infection, and B Cell Immunity. J Immunol. Feb 15;196(4):1780-9.

5. Chandrashekhar K, Gangaiah D, Pina-Mimbela R, Kassem II, Jeon BH, Rajashekara G. (2015). Transducer like proteins of Campylobacter jejuni 81-176: role in chemotaxis and colonization of the chicken gastrointestinal tract.  Front Cell Infect Microbiol. 2015 May 27;5:46.

6. Pina-Mimbela R, Madrid JA, Kumar A, Torrelles JB, Rajashekara G. (2015). Polyphosphate kinases modulate Campylobacter jejuni outer membrane constituents and alter its capacity to invade and survive in intestinal epithelial cells in vitro.Emerg Microbes Infect. Dec 30;4(11):e77.PMID: 26714783