报告题目：Constitutive activation of cellular immunity underlies the evolution of resistance to infection in Drosophila 报告人：Frank Jiggins教授，英国剑桥大学 (University of Cambridge) 时间：2020年12月16日 16:00-17:30 地点：腾讯会议ID：378 585 664 联系人：曹川 18710164086 报告人简介: 剑桥遗传系教授，获得剑桥大学本科、博士学位，2000-2003年Emmanuel College Research Fellow，2003-2008在Wellcome Trust、Royal Society资助下于爱丁堡大学进化生物学研究所工作，2009年回到剑桥大学遗传系。担任PLoS Pathogens, BMC Biology, eLife (Guest), Molecular Ecology等杂志编辑以及NERC Large Grant，Newton Fellowship等基金会评审成员。研究获得英国生物技术与生物科学基金会 (BBSRC)、自然环境研究理事会(NERC)、惠康基金 (Wellcome Trust)、英国皇家学会 (Royal Society)、欧洲莱弗休姆基金 (Leverhulme Trust)等机构资助。目前主要研究工作包括昆虫寄主与寄生生物之间的进化关系，探索影响寄主抗性的遗传多样性及其在自然种群中维持的机制。 部分代表作： Selected Publications Leitão, AB, Bian, X, Day, JP, Pitton, S, Demir, E, Jiggins, FM 2019 Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids. PLoS Pathogens. 15: e1008084. Martinez J, Klasson L, Welch JJ, Jiggins FM. 2020. Life and Death of Selfish Genes: Comparative Genomics Reveals the Dynamic Evolution of Cytoplasmic Incompatibility. Mol. Biol. Evol. Lewis S, Ross L, Bain SA, Pahita E, Smith SA, Cordaux R, Miska EA, Lenhard B, Jiggins FM 2020. Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods. PLoS Genetics. Alves, JM, Carneiro, M, Cheng, JY, Lemos de Matos, A, Rahman, MM, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Afonso, S, Bell, DJ, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, G, Nielsen, R, Gilbert, MTP, Esteves, PJ, Ferrand, N and Jiggins, FM 2019 Parallel adaptation of rabbit populations to myxoma virus. Science. 363: 1319–1326 doi: 101126/scienceaau7285 Duxbury, EML, Day, JP, Vespasiani, DM, Thüringer, Y, Tolosana, I, Smith, SCL, Tagliaferri, L, Kamacioglu, A, Lindsley, I, Love, L, Unckless, RL, Jiggins, FM*, Longdon, B* 2019 Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife. Lewis, SH, Quarles, KA, Yang, Y, Tanguy, M, Frezal, L, Smith, SA, Sharma, SP, Cordaux, R, Gilbert, C, Giraud, I, Collins, DH, Zamore, PD, Miska, EA, Sarkies, P, Jiggins, FM 2017 Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements. Nature Ecology and Evolution. 2: 174
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