基本信息

工作经历

2019.7 - 今           中国农业大学 副教授

2014.7 - 2019.6     清华大学 博士后

2008.7 - 2011.8     清华大学 科研助理

教育经历

2011.9 - 2014.7     清华大学 博士

2005.9 - 2008.7     中国科学院微生物研究所 硕士

2001.9 - 2005.7     南京农业大学 本科

教学工作

参讲课程：

1. 农药靶标与分子设计

2. 真菌生物学

3. 植物病理学研究方法

4. 高级植物病理学

5. 植物与病原物互作的蛋白组学

6. 结构与生命

研究方向

活性小分子的筛选鉴定和作用机制

科研项目

1. 国自然科学基金青年项目，真菌特异的内吞作用相关蛋白End3发挥作用的结构研究，2021.1-2023.12，主持

2. 国家重点研发计划，中法农业联合实验室，2023.10-2026.9，参与

3. 国自然科学基金地区联合基金重点项目，松树化感物质诱导三七抗性并募集根际有益微生物的机制研究，2024.1-2027.12，参与

代表性论文

1.         Kong ZW, Li SJ, Li JX, Chen YT, Chen MQ, Zhang X, Wang DL*, Liu JF*. Combinatorial targeting of common docking and ATP binding sites on Mps1 MAPK for management of pathogenic fungi. Journal of Agricultural and Food Chemistry 2024, 72(49):27115-27124.

2.         Han R, Zhu TT, Kong ZW, Zhang X, Wang DL*, Liu JF*. Understanding and manipulating the recognition of necrosis-inducing secreted protein 1 (NIS1) by BRI1-associated receptor kinase 1 (BAK1). International Journal of Biological Macromolecules 2024, 278: 134821.

3.         Han R, Zhu TT, Zhou LL, Chen MQ, Wang DL*, Liu JF*. Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2. Biochemical and Biophysical Research Communications 2024, 710: 149871.

4.         Kong ZW, Zhang X, Zhou F, Tang L, Chen YT, Li SJ, Zhang XK, Kuai LT, Su WJ, Cui WR, Cai JX, Wang YL, Yang J, Peng YL, Wang DL*, Liu JF*. Structure-aided identification of an inhibitor targets Mps1 for the management of plant-pathogenic fungi, mBio. 2023, 14, e0288322.

5.         Chen YT, Tang L, Jiang ZY, Wang SS, Qi LL, Tian XL, Deng HT, Kong ZW, Gao WQ, Zhang XK, Li SJ, Chen MQ, Zhang X, Duan HX, Yang J, Peng YL, Wang DL*, Liu JF*. Dual-specificity inhibitor targets enzymes of trehalose biosynthesis pathway. Journal of Agricultural Food Chemistry. 2023, 72: 209−218.

6.         Zheng YY, Zhang X, Liu Y, Zhu TT, Wu XF, Ning YS, Liu JF, Wang DL. Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model, Phytopathology Research 2023, 5: 31.

7.         Zhang XK, Wang C, Qi LL, Wang SW, Chen YT, Kong ZW, Li SJ, Zhang X, Zhang ZG, Liu JF, Wang DL. The tandem EH domains of End3 cooperate to interact with dual XPF motifs of Sla1 for the connection of early and late stages in fungal endocytosis. Biochemical and Biophysical Research Communications 2023, 663:147-153.

8.         Zhang X^#, Wang DL^#, Elberse J, Qi LL, Shi W, Peng YL, Schuurink RC, Van den Ackerveken G*, Liu JF*. Structure-guided analysis of the Arabidopsis jasmonate-induced oxygenase (JOX) 2 reveals key residues of plant JOX recognizing jasmonic acid substrate. Molecular Plant 2021, 14: 820-828.

9.         Wang SS, Zhao YX, Yi L, Shen MH, Wang C, Zhang X, Yang J, Peng YL, Wang DL*, Liu JF*. Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1. Biochemical Journal 2019, 476(21): 3227-3240.

10.     Cheng XK, Zhao YX, Jiang Q, Yang J, Zhao W, Taylor IA, Peng YL, Wang DL*, Liu JF*. Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain. Nucleic Acids Research 2019, 47(8): 4308-4318.

11.     Wang DL, Huang BL, Zhang SY, Yu XJ, Wu W, Wang XQ. Structural basis for R-spondin recognition by LGR4/5/6 receptors. Genes & Development 2013, 27(12): 1339-1344.

12.     Wang DL, Zhang SY, Li L, Liu X, Mei KR, Wang XQ. Structural insights into the assembly and activation of IL-1β with its receptors. Nature Immunology 2010, 11(10): 905-911.

专利

1. 国家发明专利，一种萘啶酰胺类化合物及其制备方法与应用，202210515272.X

2. 国家发明专利，一种吲哚酰胺类化合物作为海藻糖-6-磷酸合成酶抑制剂的应用，202210122745.X